Tag Archives: androgen insensivity syndrome

PREPRINT RELEASE: Prophylactic Laparoscopic Bilateral Gonadectomy for Complete Androgen Insensitivity Syndrome

Prophylactic Laparoscopic Bilateral Gonadectomy for Complete Androgen Insensitivity Syndrome
University of Arkansas for Medical Sciences

J. Corbin Norton, MD
Department of Urology
University of Arkansas for Medical Sciences

Stephen J. Canon, MD
Department of Pediatric Urology
Arkansas Children’s Hospital

Amrit Singh, MD
Department of Pathology
University of Arkansas for Medical Sciences / Arkansas Children’s Hospital

Laura L. Hollenbach, MD
Department of Obstetrics and Gynecology
University of Arkansas for Medical Sciences

Georgia Gamble, MD
Department of Obstetrics and Gynecology
University of Arkansas for Medical Sciences

Laura A. Gonzalez-Krellwitz, MD
Department of Pathology
University of Arkansas for Medical Sciences / Arkansas Children’s Hospital

The patient, in this case, is a 15-year-old female who presented with primary amenorrhea and who on work-up was found to have complete androgen insensitivity syndrome. Here, Dr. Canon at the University of Arkansas for Medical Sciences performs a prophylactic laparoscopic bilateral gonadectomy to reduce her future risk for intra-abdominal testicular malignancies. Final pathology results showed a rare case of bilateral germ cell neoplasia in situ and bilateral paratesticular leiomyomas and reinforced the decision to intervene early allowing for the removal of the gonads prior to their conversion to formal germ cell tumors.