Prophylactic Total Gastrectomy for CDH1 Gene Mutation
Zhi Ven Fong, MD, MPH; John T. Mullen, MD
Massachusetts General Hospital

Hereditary Diffuse Gastric Cancer (HDGC) syndrome is due to a mutation in the CDH1 gene that predisposes patients to a high lifetime risk of developing gastric cancer. As such, a total gastrectomy is typically recommended for patients with this syndrome. In this case, the patient presented with an incidentally discovered CDH1 mutation on genetic testing obtained after she was diagnosed with early-onset rectal cancer. In this video, Dr. Mullen at MGH demonstrates his technique for performing an open prophylactic total gastrectomy with a Roux-en-Y esophagojejunostomy reconstruction.